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This is morecost-effective than treating all patients with alonger MDT to prevent a few relapses.

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Interaction with these receptorsmodulates the expression of a series of genes involved indifferentiating these cells into neurons or glia. The microRNA miR-17-92 has been identi?ed as one of the targets for p53repression under hypoxia (0.1 % O 2 ) [ 55]

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