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There isgreat potential utility toward risk assessment in a signaturebuilt upon the results of rapid high-throughput in vitroassays. Conversely, wild-type p53 is reportedto repress expression of proangiogenic molecules such as matrix metalloprotease(MMP)-1, hypoxia-inducible factor (HIF)-1? [ 15], the HIF-1? target vascular endo-thelial cell growth factor (VEGF)-A [ 16 , 17], and cyclo-oxygenase (COX)-2 [ 18 ].Other studies also indicate that some pro-angiogenic chemokines [ 19 ], includingCXCL12, CXCL8 and CXCL5, are repressed by wild-type p53 [ 20 , 21].
Louis (1998) noted that, in an attempt tohandle these rather unwieldy phrases, “‘PWS’ (meaning ‘person who stutters’) or ‘CWS’(or ‘child who stutters’) have become acronyms, at first only in writing, but recently inverbal descriptions as well.” He goes on to question whether calling someone “a ‘PWS’really communicates more sensitivity than referring to him as a ‘stutterer.’” Whether aclinician, researcher, or both, the use of preferred labels does not, in itself, confer dignity,respect, or caring. Womenconsume psychotropic drugs in far greater quantities than men (Olson and Pincus 1994a). The inset, which shows theboxed area, reveals several nuclei, two of which belong to the musclefibers (MF).
William George Black’s (1967)Folk-Medicine: A Chapter in the History of Culture, the preface of whichdates the work to 1883, is an excellent example of such an approach. A surface swab that was taken from his wound 3 weeks after injury grew fullysensitive S. Electron micrograph of the zonulaadherens from Figure 5.14a at higher magnification. Glycogen appears inEM as granules 25 to 30 nm in diameter or as clustersofgranules that often occupy significant portions of thecytoplasm (Fig.
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